Emergency services are responding to a three car crash at the intersection of Kyogle Rd and Rifle Range Rd at Tuncester.
A NSW Ambulance spokeswoman said initial reports of a two car crash had been upgraded to a three car incident.
Witnesses at the scene described a collision between two four-wheel drives and a station wagon.
Paramedics have just arrived on scene and are yet to assess patients or determine if people are trapped.
Police rescue is responding from Lismore.
More updates as they come to hand.
Paramedics on scene are tending to three patients involved in the crash.
A NSW Ambulance spokeswoman said a 65-year-old woman was being treated for a chest injury.
A 60-year-old woman driver of one of the vehicles was transported to Lismore Base Hospital in a stable condition with multiple injuries.
Paramedics are also assessing another female patient who is suffering neck pain and another patient whose sex and condition are unknown.