FIRE & Rescue NSW Lismore station officer David Mooney said the truck cab was well alight when they first arrived at the scene of a crash on Bangalow Rd.
Mr Mooney said the truck had contained camellia oil, which was biodegradable and not a hazard to the surrounding environment.
The driver was taken to Lismore Base Hospital to be stabilised, and he's expected to soon be flown to a Brisbane hospital.
He has suffered severe facial burns from the incident.
Police have been approached for comment.