Denyer wasn't expected to win over his Channel 10 stablemate Amanda Keller or A Current Affair's Tracy Grimshaw.
In an emotional acceptance speech, Denyer credited the now axed game show for helping him to get out of a dark time in his life.
"Family Feud came along for me in my life at a time when I really wasn't quite sure if I'd work again, or if I wanted to," he said.
"I wasn't in a very good place. I wasn't very well; I was in a bit of a hole; I was sad; I was a bit lost, in fact I was very unwell at that particular time. Family Feud gave me a ladder out of that hole and I'm very lucky to have had it. It gave me my mojo back.
"Family Feud thank you so much, you saved me."
Denyer also thanked his wife, dedicating the award to her, and Gleeson for galvanising his Logies campaign.
"Tom Gleeson, thanks. Sometimes in this country you need an angry redhead to get things done, and Pauline Hanson wasn't available."
Opening the show, host Dave Hughes has led the night and its long list of jokes at other stars' expense.
TV veteran Bert Newton stunned everyone when he launched into detailing his resume since 1957 - with a few clangers.
He made a strange reference to Graham Kennedy and Don Lane mentoring young talent. Many took offence, asking on social media if he was referring to Kennedy being once a sexual predator.
He later thanked his wife Patti for taking up his religion of having a TAB account and drinking red wine, after comparing the move to the way Waleed Aly's wife Susan Carland had coverted to Islam for him.
He also referred to himself being an "old p**f" on stage, which some people thought was "homophobic".
Don't use the word poof, ever. It's not funny & as a gay man who grew up in regional Queensland - had it directed to me as a teenager, full of poison. It hurts to hear. #TVWeekLogies
MasterChef's George Calombaris and Gold Logie dark horse Andrew Winter also copped flak as Hughesy let rip on some of the biggest stars in the TV industry.
Grant Denyer also quipped that it was funny to be getting a Logie for the first time in 22 years when his show, Family Feud had been axed.
Selfies were taken on the red carpet as the Today show cast arrived and Carrie Bickmore and Lisa Wilkinson bumped into each other. Bickmore also revealed her new baby bump.
60 Minutes also took out the Hall of Fame award despite courting controversy that put the show's reputation at stake.
The Voice coach Kelly Rowland performed a medley of Destiny's Child's Survivorand her own When Love Takes Over, as a duet with her winning Voice artist, loop performer Sam Perry.
Perry's voice was like gravel in mud and strangely, Rowland seemed to struggle too: She aimed high with the big final note in Survivor but her voice faltered like a limp balloon.
By the end of the performance, she was relying on pre-recorded backing vocals and passing the mic to audience members and to help pick up the slack. Audience members like Safe Harbour actor Hazem Shammus who... didn't seem to know the words:
Julia Morris certainly brought the energy this year in a song and dance number before she presented the award for Most Popular Drama to Foxtel's Wentworth - who seemed quite surprised with the win, dropping a shocked "bulls**t" live on camera:
There were emotional scenes as the team from Ten's The Living Room took home the award for Most Popular Lifestyle Program, after presenter Barry DuBois' very public cancer battle over the past 12 months.
"In television sometimes we focus on too much on key demographics, time slots and ratings when all that really matters is your health and your happiness. That's why while this award is truly special, the biggest reward for us is having Barry DuBois with us tonight," said Chris Brown.
"To have the four of us up here holding hands... we didn't know this time last year whether we would have this. This is extraordinary for us," said Amanda Keller.
2018 Logie Award winners
TV WEEK GOLD LOGIE
Grant Denyer (Family Feud/All Star Family Feud, Network Ten) WINNER
Amanda Keller (The Living Room, Network Ten)
Andrew Winter (Love It Or List It Australia/Selling Houses Australia,
Foxtel - Lifestyle)
Jessica Marais (Love Child, Nine Network; The Wrong Girl, Network Ten)
Rodger Corser (Doctor Doctor, Nine Network)
Tracy Grimshaw (A Current Affair, Nine Network)
MOST OUTSTANDING ACTRESS
Elisabeth Moss (Robin Griffin, Top Of The Lake: China Girl, Foxtel - BBC First)
Kate Atkinson (Vera Bennett, Wentworth, Foxtel - Showcase)