POLICE seized more than $150,000 worth of cannabis in raids at Brunswick Heads, Murwillumbah, Bogangar and Mount Burrell.
Four men have been charged and one offender is yet to be found.
Officers from the Tweed/Byron Target Action Group searched the properties on Tuesday and Wednesday.
Two properties at Brunswick Heads were raided and police seized $42,000 worth of cannabis plants.
A 59-year-old man and a 37-year-old man have been charged and will face Mullumbimby Local Court.
At Bogangar, police seized 26 cannabis plants, reaching up to 2.5 metres tall and worth an estimated $52,000, growing in a secured section of a back yard.
A 38-year-old man was charged with cultivating a prohibited plant (cannabis) and will appear at Tweed Heads Local Court later this month.
At a Murwillumbah residence, police found nine cannabis plants growing in an elaborate hydroponic set-up with a street value of about $36,000.
They also seized chemicals and hydroponic lights at the Mooball Street home.
A 58-year-old man was charged with enhancing the cultivation of a prohibited plant (cannabis) and will appear at Murwillumbah Local Court.
Officers also seized a dozen plants from bushland in Uki Road, Mount Burrell, on Wednesday, but are still investigating to find the owner of the drugs.
Tweed/Byron crime manager, Insp Greg Carey, encouraged members of the public to provide information to police on the growing or manufacturing of drugs.
Anyone with information should call Crime Stoppers on 1800 333 000.